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Antimicrob. Agents Chemother. · Dec 2002
Clinical TrialHigh concentrations of nelfinavir as an independent risk factor for lipodystrophy in human immunodeficiency virus-infected patients.
- Jean-Marc Tréluyer, Jean-Pierre Morini, Jérome Dimet, Isabelle Gorin, Elisabeth Rey, Jean Deleuze, Pierre-François Ceccaldi, Jean-Paul Escande, Gérard Pons, and Nicolas Dupin.
- Pharmacologie Périnatale et Pédiatrique, Groupe Hospitalier Cochin-Saint Vincent de Paul (AP-HP), Université René Descartes, 75674 Paris Cedex 14, France. jm.treluyer@svp.ap-hop-paris.fr
- Antimicrob. Agents Chemother. 2002 Dec 1; 46 (12): 4009-12.
AbstractTo assess the relationship between antiretroviral drug exposure and lipodystrophy, 69 human immunodeficiency virus type 1-infected patients receiving nelfinavir were investigated cross-sectionally. Lipodystrophy was defined by patients' self-report. Nelfinavir trough concentrations in plasma were significantly related to overall lipodystrophy and peripheral fat wasting scores and appeared to be an independent risk factor for lipodystrophy
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