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Adv. Drug Deliv. Rev. · Feb 2010
Comparative Study Historical ArticleHPMA copolymers: origins, early developments, present, and future.
- Jindrich Kopecek and Pavla Kopecková.
- Department of Pharmaceutics and Pharmaceutical Chemistry, Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA. Jindrich.kopecek@utah.edu
- Adv. Drug Deliv. Rev. 2010 Feb 17; 62 (2): 122-49.
AbstractThe overview covers the discovery of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers, initial studies on their synthesis, evaluation of biological properties, and explorations of their potential as carriers of biologically active compounds in general and anticancer drugs in particular. The focus is on the research in the authors' laboratory - the development of macromolecular therapeutics for the treatment of cancer and musculoskeletal diseases. In addition, the evaluation of HPMA (co)polymers as building blocks of modified and new biomaterials is presented: the utilization of semitelechelic poly(HPMA) and HPMA copolymers for the modification of biomaterial and protein surfaces and the design of hybrid block and graft HPMA copolymers that self-assemble into smart hydrogels. Finally, suggestions for the design of second-generation macromolecular therapeutics are portrayed.Copyright 2009 Elsevier B.V. All rights reserved.
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