• Internal medicine · May 2022

    Case Reports

    Mixed Infection of Cytomegalovirus and Pulmonary Nocardiosis Caused by Nocardia elegans Diagnosed Using Nanopore Sequencing Technology: A Case Report.

    • Chie Watanabe, Yoshifumi Kimizuka, Yuji Fujikura, Takaaki Hamamoto, Akira Watanabe, Takashi Yaguchi, Tomoya Sano, Ryohei Suematsu, Yoshiki Kato, Jun Miyata, Susumu Matsukuma, and Akihiko Kawana.
    • Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan.
    • Intern. Med. 2022 May 15; 61 (10): 1613-1617.

    AbstractA 69-year-old woman who had undergone renal transplantation and was receiving sulfamethoxazole/trimethoprim (ST) developed pulmonary nocardiosis. To our knowledge, this is the first report of the identification of Nocardia elegans using nanopore sequencing, supported by 16S rDNA capillary sequencing findings. Chest computed tomography performed after ST initiation revealed significant improvement of the pulmonary shadows compared to previous findings. We herein report the value of nanopore sequencing for rapid identification of rare pathogens, such as Nocardia elegans. Furthermore, our findings suggest that Nocardia may infect even patients receiving ST, which is currently the most effective prophylactic drug.

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