• Gerard Thompson, Samantha Jane Mills, Stavros Michael Stivaros, and Alan Jackson.
• School of Cancer and Imaging Sciences, Wolfson Molecular Imaging Centre, The University of Manchester, 27 Palatine Road, Manchester, England M20 3LJ, UK. gerard.thompson@manchester.ac.uk
• Neuroimaging Clin. N. Am. 2010 Aug 1; 20 (3): 337-53.

AbstractThe use of biomarkers of microvascular structure and function from perfusion and permeability imaging is now well established in neuro-oncological research. There remain significant challenges to be overcome before these techniques and related biomarkers can find general clinical acceptance. Core to this is the standardization of acquisition and processing protocols for robust use across multiple clinical sites. The potential clinical benefits of these approaches are already becoming clear, particularly in the setting of novel antiangiogenic therapies. With an increasing body of evidence in the scientific literature, and with a steadily falling barrier to entry, the coming decade should see rapid developments in imaging biomarkers, and facilitate their transition into routine clinical practice.Copyright 2010 Elsevier Inc. All rights reserved.

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