• Jian Gu, Yihua Wang, and Juanhan Yu.
• Department of Pathology, the First Affiliated Hospital of China Medical University,Shenyang, China.
• Medicine (Baltimore). 2021 Oct 29; 100 (43): e27570e27570.

RationaleAstroblastoma is a rare tumor of the central nervous system with uncertain biological behavior and origin. Its histopathological features have been well established, while, to our knowledge, astroblastoma with oligodendroglial-like cells have not been reported.Patient ConcernsA 15-year-old girl presented with nausea, vomiting, headache, and visual disturbance.DiagnosisMagnetic resonance imaging revealed a large neoplasm in the left temporal. Histologically, the tumor showed solid and pseudopapillary structure. Immunohistochemical staining showed that the tumor cells were positive for glial fibrillary acidic protein and vimentin. The oligodendroglial-like cells were positive for glial fibrillary acidic protein, vimentin, and oligodendrocyte transcription factor 2. The antigen KI67 labeling index was about 4%. Sequencing for isocitrate dehydrogenase (IDH) 1 codon 132 and IDH2 codon 172 gene mutations showed negative results. Furthermore, fluorescent analysis revealed neither 1p nor 19q deletion in the lesion. Based on these findings, the girl was finally diagnosed as astroblastoma.InterventionsA craniotomy with total excision of the tumor was performed.OutcomesThe follow-up time was 1 year, no evidence of disease recurrence was found in magnetic resonance imaging.LessonsCerebral astroblastoma with oligodendroglial-like cells is a clinically rare tumor of central nervous system. Clear distinction and diagnosis are critical.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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