• Hsuan Huang and Yi-Hsin Lin.
• Division of Pediatric Surgery, Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan (R.O.C.).
• Medicine (Baltimore). 2021 Oct 29; 100 (43): e27612e27612.

IntroductionEctopic thyroid tissue presenting at the base of the tongue, called lingual thyroid, is a clinical rarity. Clinical presentation varies depending upon either the severity of regional symptoms associated with the enlargement of gland size, or the features related to thyroid dysfunction.Patient ConcernsWe reported a case of a 29-year-old female who presented with symptoms of easy fatigue and depression for 3 months.DiagnosisAfter a series of diagnostic workup, the lingual thyroid with severe hypothyroidism was diagnosed.Intervention And OutcomeShe received conservative treatment with thyroid hormone replacement and the symptoms improved significantly.LessonsLingual thyroid is a rare entity that needs careful diagnostic workup including clinical examination, biochemical tests, imaging methods such as ultrasonography, scintigraphy, computed tomography, magnetic resonance imaging, and fine-needle aspiration cytology to plan the management. Lingual thyroid with hypothyroidism and no neck regional symptoms can be conservatively treated and requires regular follow-up for the prevention of potential risk of malignant transformation.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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