• Qiongjie Zhu, Wenjin Xu, and Xuesong Li.
• Department of Traditional Chinese Medicine, Wuhan Asia General Hospital, Wuhan, Hubei, China.
• Medicine (Baltimore). 2021 Oct 29; 100 (43): e27646e27646.

BackgroundFrom the perspective of evidence-based medicine, the efficacy and safety of combined therapy for marrow suppression after chemotherapy is still unclear. Given that there is no high-quality meta-analysis to incorporate existing evidence, the purpose of this protocol is to design a systematically review and meta-analysis of the level I evidence to ascertain the efficacy and safety of acupuncture combined with traditional Chinese medicine preparation for marrow suppression after chemotherapy.MethodsThe following databases will be searched electronically by keyword combination mode: 4 British literature databases including PubMed, EMBASE, Scopus, and Cochrane Library, and 4 Chinese literature databases, including Chinese national knowledge infrastructure, VIP, and Wan fang database. The randomized controlled trials on acupuncture plus traditional Chinese medicine preparation for marrow suppression after chemotherapy will be included. The primary outcome is the elevation of hemoglobin, platelets, leukocytes, and neutrophils. The other outcomes include clinical symptoms, quality of life, and absolute value of reticulocyte. Risk bias analysis of the studies will be performed independently by 2 reviewers using the Cochrane Risk of Bias Assessment Tool.ResultsThe review will add to the existing literature by showing compelling evidence and improved guidance in clinic settings.ConclusionThis protocol will provide a reliable theoretical basis for the following research.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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