-
Fetal Pediatr Pathol · Feb 2014
Proportionate reduction in uncertainty of late onset infection in pre-term infants by neutrophil CD64 measurement.
- Janet Elizabeth Berrington, Richard Iain Hearn, Chris Hall, Christopher James Stewart, Stephen Paul Cummings, and Nicholas David Embleton.
- Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Neonatal Service, Royal Victoria Infirmary , Newcastle upon Tyne , United Kingdom.
- Fetal Pediatr Pathol. 2014 Feb 1; 33 (1): 16-22.
ObjectiveEstablish how neutrophil CD64 performs as a marker of definite infection in pre-term infants in comparison to C reactive protein (CRP) and procalcitonin (PCT).MethodsA total of 38 pre-term infants with suspected late onset infection had CD64 measured by flow cytometry. Proportionate reduction in uncertainty (PRU) curves were generated for CD64 counts at various threshold values.ResultsPRU curves reduced the residual uncertainty of the presence of infection by up to 64%.ConclusionsThe CD64 appears to be a useful point of care test (POCT) for further defining the likelihood of infection and performs better than CRP or PCT at helping to rule in infection.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..