• Lupus · Mar 2017

    Case Reports

    A case of drug-induced lupus erythematosus secondary to trimethoprim/sulfamethoxazole presenting with pleural effusions and pericardial tamponade.

    • A Jose, A K Cramer, K Davar, and G Gutierrez.
    • Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University, Washington, DC, USA.
    • Lupus. 2017 Mar 1; 26 (3): 316-319.

    AbstractWe report a case of drug-induced lupus erythematosus (DILE) secondary to trimethoprim/sulfamethoxazole (TMP/SMX) in a patient with underlying inflammatory bowel disease (IBD). The initial presentation was with febrile pleural and pericardial effusions followed by cardiac tamponade. The patient was treated with a short course of corticosteroids with complete resolution of symptoms. To our knowledge this is the first reported case of TMP/SMX-induced DILE presenting with life-threatening serositis. When confronted with sterile exudative effusions, clinicians should strongly consider non-infectious etiologies.

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