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- S W Krause and A Mackensen.
- Medizinische Klinik 5, Universitätsklinikum Erlangen, Erlangen, Deutschland.
- Internist (Berl). 2008 Dec 1; 49 (12): 1452-7.
AbstractChronic myeloproliferative diseases (CMPD) are haematopoetic neoplasias with indolent course and preserved cellular function of the maturing malignant cells. In Philadelphia-positive chronic myeloid leukaemia the discovery of molecular disease mechanisms led to the successful introduction of targeted therapy with imatinib. Ph-negative CMPD are conventionally treated by cytoreduction and low dose ASS in order to minimise the risk of vascular complications. For all CMPD, lifelong surveillance and therapy are necessary.
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