• Southern medical journal · Nov 2021

    Fibrin-Associated Diffuse Large B Cell Lymphoma Found on Revision Arthroplasty of the Knee.

    • Jordan Hall, Craig Kampfer, Ned Williams, Michael Osswald, Bradie Bishop, Misty Hall, and Joseph Alderete.
    • From the Departments of Pathology, Orthopedic Surgery, Radiation Oncology, and Hematology Oncology, Brooke Army Medical Center, Joint Base San Antonio, Texas.
    • South. Med. J. 2021 Nov 1; 114 (11): 708-713.

    AbstractFibrin-associated diffuse large B cell lymphoma (FA-DLBCL) is a rare Epstein-Barr viruspositive B cell lymphoma that is nonmass-forming, does not directly produce symptoms, and is incidentally discovered on histological examination of tissues excised for other reasons. Despite overlap in morphologic and immunophenotypic features with aggressive B cell neoplasms, FA-DLBCL shows an excellent clinical outcome, even with surgical excision alone. We report an extremely rare occurrence of FA-DLBCL found in association with a metallic implant on revision arthroplasty of the knee. This report also illustrates the need for an integrated multidisciplinary approach for accurate diagnosis and avoidance of overtreatment.

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