• Nikolaos Zamboglou, Nikolaos Tselis, Dimos Baltas, Thomas Buhleier, Thomas Martin, Natasa Milickovic, Sokratis Papaioannou, Hanns Ackermann, and Ulf W Tunn.
• Department of Radiation Oncology, Klinikum Offenbach, Offenbach, Germany.
• Int. J. Radiat. Oncol. Biol. Phys. 2013 Mar 1; 85 (3): 672-8.

PurposeTo report the clinical outcome of high-dose-rate (HDR) interstitial (IRT) brachytherapy (BRT) as sole treatment (monotherapy) for clinically localized prostate cancer.Methods And MaterialsBetween January 2002 and December 2009, 718 consecutive patients with clinically localized prostate cancer were treated with transrectal ultrasound (TRUS)-guided HDR monotherapy. Three treatment protocols were applied; 141 patients received 38.0 Gy using one implant in 4 fractions of 9.5 Gy with computed tomography-based treatment planning; 351 patients received 38.0 Gy in 4 fractions of 9.5 Gy, using 2 implants (2 weeks apart) and intraoperative TRUS real-time treatment planning; and 226 patients received 34.5 Gy, using 3 single-fraction implants of 11.5 Gy (3 weeks apart) and intraoperative TRUS real-time treatment planning. Biochemical failure was defined according to the Phoenix consensus, and toxicity was evaluated using Common Toxicity Criteria for Adverse Events version 3.ResultsThe median follow-up time was 52.8 months. The 36-, 60-, and 96-month biochemical control and metastasis-free survival rates for the entire cohort were 97%, 94%, and 90% and 99%, 98%, and 97%, respectively. Toxicity was scored per event, with 5.4% acute grade 3 genitourinary and 0.2% acute grade 3 gastrointestinal toxicity. Late grade 3 genitourinary and gastrointestinal toxicities were 3.5% and 1.6%, respectively. Two patients developed grade 4 incontinence. No other instance of grade 4 or greater acute or late toxicity was reported.ConclusionOur results confirm IRT-HDR-BRT is safe and effective as monotherapy for clinically localized prostate cancer.Copyright © 2013 Elsevier Inc. All rights reserved.

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