• Wim Vandenberghe, Lien Van Laethem, Ingrid Herck, Harlinde Peperstraete, Hannah Schaubroeck, Alexander Zarbock, Melanie Meersch, Annemieke Dhondt, Sigurd Delanghe, Jill Vanmassenhove, Jan J De Waele, and HosteEric A JEAJDepartment of Intensive Care Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium; Research Foundation-Flanders (FWO), Brussels, Belgium..
• Department of Intensive Care Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium. Electronic address: WimVDB.Vandenberghe@Ugent.be.
• J Crit Care. 2022 Feb 1; 67: 108-117.

PurposeCardiac surgery associated acute kidney injury (CSA-AKI) is a contributor to adverse outcomes. Preventive measures reduce AKI incidence in high risk patients, identified by biomarkers [TIMP-2]*[IGFBP7] (Nephrocheck®). This study investigate clinical AKI risk assessment by healthcare professionals and the added value of the biomarker result.Materials And MethodsAdult patients were prospectively included. Healthcare professionals predicted CSA-AKI, with and without biomarker result knowledge. Predicted outcomes were AKI based on creatinine, AKI stage 3 on urine output, anuria and use of kidney replacement therapy (KRT).ResultsOne-hundred patients were included. Consultant and ICU residents were best in AKI prediction, respectively AUROC 0.769 (95% CI, 0.672-0.850) and 0.702 (95% CI, 0.599-0.791). AUROC of NephroCheck® was 0.541 (95% CI, 0.438-0.642). AKI 3 occurred in only 4 patients; there was no anuria or use of KRT. ICU nurses and ICU residents had an AUROC for prediction of AKI 3 of respectively 0.867 (95% CI, 0.780-0.929) and 0.809 (95% CI, 0.716-0.883); for NephroCheck® this was 0.838 (95% CI, 0.750-0.904).ConclusionsHealthcare professionals performed poor or fair in predicting CSA-AKI and knowledge of Nephrocheck® result did not improved prediction. No conclusions could be made for prediction of severe AKI, due to limited number of events.Copyright © 2021 Elsevier Inc. All rights reserved.

15 keywords...

hide…