• Qi Wang, Fei Wang, Fengwei Fu, Jinlin Liu, Weilu Sun, and Yongqing Chen.
• Neurorehabilitation Center, Beijing Rehabilitation Hospital of Capital Medical University, Beijing 100144, China.
• Clinics (Sao Paulo). 2021 Jan 1; 76: e2958.

ObjectivesTo investigate the clinical utility of serum microRNA levels (miR-9-5p and miR-128-3p) in the diagnosis and prognosis of early-stage acute ischemic stroke (AIS).MethodsWe compared the differences in serum miR-9-5p and miR-128-3p levels between patients with AIS and healthy individuals (controls). The serum levels of miR-9-5p and miR-128-3p were quantified using quantitative real-time PCR, and the association of each miRNA with AIS was determined using receiver operator characteristic curve analysis. The predictive value of these indices in the diagnosis of early-stage AIS was evaluated in conjunction with that of computed tomography findings and neuron-specific enolase levels. The prognosis of patients with AIS was evaluated three months after their discharge from hospital using the modified Rankin scale, which classifies the prognosis as either favorable or poor. Logistic regression analysis was used to analyze the correlation between miR-9-5p and miR-128-3p levels and patient prognosis.ResultsThe serum levels of miR-9-5p and miR-128-3p were upregulated in patients with AIS relative to those in healthy individuals. A pronounced correlation was identified between serum miR-9-5p and miR-128-3p levels and patient prognosis, with high levels of both miRNAs being associated with poor patient outcomes.ConclusionAssessment of serum miR-9-5p and miR-128-3p levels is important for the early diagnosis and prognosis of AIS.

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