• J Rheumatol · Sep 2009

    Comparative Study

    Observations on cryoglobulin testing: I. The association of cryoglobulins containing rheumatoid factors with manifestation of cryoglobulinemic vasculitis.

    • Francesco G De Rosa and Vincent Agnello.
    • Department of Laboratory Medicine, Lahey Clinic, Burlington, MA 01805, USA.
    • J Rheumatol. 2009 Sep 1; 36 (9): 1953-5.

    ObjectiveTo investigate the results of mixed cryoglobulin tests performed on patients with and without hepatitis C virus (HCV) infection, to determine whether type II cryoglobulins containing rheumatoid factor (Type II-RF) were associated with cryoglobulinemic vasculitis.MethodsThe cryoglobulin test protocol differed from the routine protocol. In addition to determination of both cryoglobulin concentration and immunoglobulin composition, the presence or absence of RF concentrated in the cryoglobulins was determined.ResultsA qualitative and quantitative association of Type II-RF cryoglobulins with cryoglobulinemic vasculitis was present among HCV-infected patients.ConclusionDetection and quantification of Type II-RF may enhance clinical monitoring of cryoglobulinemic vasculitis in HCV-infected patients.

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