• Int. J. Tuberc. Lung Dis. · Aug 2020

    Assessment of knee extensor and flexor function using isokinetic test in COPD: impact on exercise capacity.

    • P Li, Z Wang, Y Lu, N Li, L Xiao, J Su, H Duan, X Liu, and W Wu.
    • Department of Sports Medicine, Shanghai University of Sport, Shanghai.
    • Int. J. Tuberc. Lung Dis. 2020 Aug 1; 24 (8): 776-781.

    ObjectiveTo quantify the relationship between strength and endurance of knee extensor and flexor and exercise capacity in patients with chronic obstructive pulmonary disease (COPD).MethodsA total of 108 patients with stable COPD (age: 65 years, IQR25-75: 59-72) were enrolled in this cross-sectional study. Knee extensor and flexor function was evaluated using the isokinetic test, and the parameters attained were considered as independent variables. Exercise capacity was evaluated using 6-minute walking test (6MWT) and 30-second sit-to-stand test (30s SST), and the results were considered as dependent variables. The association between lower-limb muscle function and exercise capacity was assessed using multiple regression analysis.ResultsThe patients mostly had moderate-to-severe airflow obstruction with a post-bronchodilator forced expiratory volume in 1 second (FEV1) of 57.87 ± 17.71% predicted. In multiple regression analysis, flexor total work (TW), extensor endurance ratio (ER), age and FEV1%pred were significantly associated with 6MWT (adjusted R² = 0.455, P < 0.001). Flexor TW and age were significantly associated with 30s SST (adjusted R² = 0.355, P < 0.001).ConclusionKnee endurance has a significant relationship with exercise capacity, and knee flexor endurance seems to be an important factor contributing to exercise capacity in COPD patients.

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