• Current oncology reports · Nov 2005

    Review

    New paradigms for therapy for osteosarcoma.

    • Rajaram Nagarajan, Denis Clohisy, and Brenda Weigel.
    • Pediatric Epidemiology and Clinical Research, University of Minnesota, Mayo Mail Code 484, 420 Delaware Street SE, Minneapolis, MN 55455, USA. nagar003@umn.edu
    • Curr Oncol Rep. 2005 Nov 1; 7 (6): 410-4.

    AbstractOsteosarcoma is a primary bone malignancy generally affecting the young, with 60% of cases occurring before the age of 25 years and the peak incidence at 15 years. Survival has improved over the past several decades, with non- metastatic disease having an approximately 70% chance of long-term survival. Unfortunately, patients with metastatic disease at diagnosis or those who have recurrent disease have a dismal prognosis, with approximately 20% surviving long term. In this review article we describe several new therapies in development for osteosarcoma. These include immune-based therapies, strategies to inhibit tumor growth, radiotherapy, and the introduction of new chemotherapies and targets.

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