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Editorial Comment
Meta-analyses of clinical trials: are we getting lemonade from lemons?
- Karsten Bartels and Daniel I Sessler.
- Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, USA; Outcomes Research Consortium, Cleveland, OH, USA. Electronic address: karbartels@unmc.edu.
- Br J Anaesth. 2022 Feb 1; 128 (2): 233-235.
AbstractMeta-analyses guide planning of clinical trials and clinical care, but are subject to all the methodologic problems and potential biases present in the underlying trials. Furthermore, publication bias often contributes to overestimated benefit in meta-analyses of small trials, which are often 'corrected' by subsequent large trials. Meta-analyses are no substitute for large robust trials.Copyright © 2021 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.
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