• Kara Bellai-Dussault, Lynn Meng, Tianhua Huang, Jessica Reszel, Mark Walker, Andrea Lanes, Nan Okun, Christine Armour, and Shelley Dougan.
• Better Outcomes Registry & Network (BORN) Ontario, Ottawa, Ontario, Canada.
• Prenat. Diagn. 2020 Jan 1; 40 (2): 164-172.

ObjectiveOntario offers a publicly funded modified contingent model of prenatal screening for aneuploidy in which cell-free DNA (cfDNA) screening is covered for pregnancies at higher risk of fetal aneuploidy. The objective of this study was to review utilization of provincially funded cfDNA screening and adherence to the criteria laid out in Ontario prenatal screening guidelines.MethodsThis was a descriptive cohort study using data collected by Ontario's prescribed maternal and child registry. The study population included all pregnant individuals who received cfDNA screening from January 2016 to December 2017.ResultsThe most common criteria for provincially funded cfDNA screening were advanced maternal age ≥40 years (37.7%), positive multiple marker screen (34.1%), modifying risk factors such as ultrasound soft markers (7.1%), and previous aneuploidy (5.5%). The audit demonstrated that 2.9% of funded cfDNA screens tests did not meet funding criteria, and that 11.4% of self-paid cfDNA screens could have been publicly funded.ConclusionReviewing and auditing the application of criteria for funded cfDNA screening using prescribed registry data allows an opportunity to identify areas where targeted education may improve adherence to standardized screening protocols, and provides a basis for reassessment of the funding model.© 2019 John Wiley & Sons, Ltd.

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