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Case Reports
Expression of aquaporin-1 in a long-term peritoneal dialysis patient with impaired transcellular water transport.
- E Goffin, S Combet, F Jamar, J P Cosyns, and O Devuyst.
- Department of Pathology, University of Louvain Medical School, Brussels, Belgium. goffin@nefr.ucl.ac.be
- Am. J. Kidney Dis. 1999 Feb 1; 33 (2): 383-8.
AbstractAquaporin-1 (AQP1) has been claimed to be the molecular counterpart of the transcellular pathway for free-water movement across the peritoneum during peritoneal dialysis. We report the case of a 67-year-old man, on peritoneal dialysis for 11 years, in whom ultrafiltration failure due to an abolition of the transcellular water transfer (documented by a loss of sodium sieving) was associated with an apparently normal expression of AQP1. We suggest that an alteration of AQP1 structure, rather than of its expression, accounts for this observation.
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