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- Shailesh Bihari, Dani-Louise Dixon, Thomas Painter, Paul Myles, and Andrew D Bersten.
- College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
- Crit Care Explor. 2021 Jan 1; 3 (1): e0316.
AbstractLiberal fluid strategies in critically ill patients are associated with harm, thought to be due to endothelial and glycocalyx injury. As the restrictive versus liberal fluid therapy for major abdominal surgery trial not only failed to report survival benefit with restrictive fluids but was associated with a higher rate of acute kidney injury, we hypothesized that factors other than endothelial and glycocalyx injury were likely to account for these findings. Consequently, we measured injury biomarkers in a cohort of the restrictive versus liberal fluid therapy for major abdominal surgery trial.Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.
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