Challenges in drug delivery to tumors of the central nervous

Adv. Drug Deliv. Rev. · May 2012

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Challenges in drug delivery to tumors of the central nervous system: an overview of pharmacological and surgical considerations.

The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption.

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- Laura P Serwer and C David James.
- Department of Neurological Surgery, University of California - San Francisco, San Francisco, CA 94158, United States.
- Adv. Drug Deliv. Rev. 2012 May 15; 64 (7): 590-7.
AbstractThe majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption.Copyright © 2012 Elsevier B.V. All rights reserved.

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Challenges in drug delivery to tumors of the central nervous system: an overview of pharmacological and surgical considerations.

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