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Adv. Drug Deliv. Rev. · May 2012
ReviewChallenges in drug delivery to tumors of the central nervous system: an overview of pharmacological and surgical considerations.
- Laura P Serwer and C David James.
- Department of Neurological Surgery, University of California - San Francisco, San Francisco, CA 94158, United States.
- Adv. Drug Deliv. Rev. 2012 May 15; 64 (7): 590-7.
AbstractThe majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption.Copyright © 2012 Elsevier B.V. All rights reserved.
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