• Microsurgery · Jan 2002

    Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.

    • Lijiang Sun, Yujun Li, Jingsen Shi, Xiao Wang, and Xiang Wang.
    • Department of Urology, Huashan Hospital, School of Medicine, Fudan University, Shanghai, P. R. China.
    • Microsurgery. 2002 Jan 1; 22 (8): 343-6.

    AbstractTo investigate the protective effects of ligustrazine on renal ischemia-reperfusion injury, the influence of ligustrazine injection on plasma superoxide dismutase (SOD), malondialdehyde (MDA), and endothelin-1 (ET-1), as well as changes of morphology of renal tubules, were studied in rat kidney models with ischemia-reperfusion injury. The results showed that in the group treated with ligustrazine, the plasma SOD level was significantly higher than that of the control group (P < 0.05), but levels of plasma MDA and ET-1 and the pathological grading of injured renal tubules were significantly lower than those in the control group (P < 0.05). These findings suggest that ligustrazine has protective effects against ischemia-reperfusion injury in rat kidneys.Copyright 2002 Wiley-Liss, Inc. MICROSURGERY 22:343-346 2002

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