• Clin Toxicol (Phila) · May 2010

    Case Reports

    Bupropion toxicokinetic: a case report.

    • Kieran Donnelly, Hannah Beth Walkowiak, Christopher Donnelly, Emma Jenkinson, Jonha Rizkalla, and Nigel Langford.
    • Department of Anaesthetics, UHB NHS Trust, Sellyoak, Birmingham, UK. kdonnelly2@nhs.net <kdonnelly2@nhs.net>
    • Clin Toxicol (Phila). 2010 May 1;48(4):385-7.

    ContextThe toxicokinetics of sustained-release bupropion are not well described.CaseA 23-year-old Caucasian male took an overdose of 5,700 mg of sustained release bupropion with no co-ingestant. Venous serum samples were assayed for bupropion concentrations over the next 5 days. The peak concentration was 1.114 mg/L. The observed T(max) was found to be 8.25 h, the calculated alpha half-life 10.9 h (+/-SE of 4.47%), and the calculated beta half-life 19.8 h (+/-SE 12.62%). The alpha half-life and T(max) differ significantly from those seen in therapeutic doses.DiscussionBezoar formation may underlie these differences. Interventions which reduce the absorption of sustained release bupropion may be effective in overdose.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…