• Mubin Hosnuter, Cenk Melikoglu, Cem Aslan, Gulcan Saglam, and Recep Sutcu.
• Department of Plastic, Reconstructive and Aesthetic Surgery, Katip Celebi University School of Medicine, Ataturk Training and Research Hospital, Izmir, Turkey.
• Adv Clin Exp Med. 2015 May 1; 24 (3): 409-17.

BackgroundEpigallocatechin gallate (EGCG), a green tea polyphenol, has potent antioxidant properties.ObjectivesThe purpose of the present study was to examine the possible preventative effects of EGCG against internal organ injury due to large-surface skin burns in a rat model.Material And MethodsThe study design involved three groups of rats: a sham group and two groups with 25-30% full-thickness burns: (a) the sham group without burns or treatment (n=18); (b) the control burn group (burns+sterile saline, n=18); and (c) the burn treatment group (burns+treatment with EGCG, n=18). EGCG was administered intraperitoneally immediately after the thermal injury, and daily in 100 μmol/kg doses. Kidney and lung tissue samples were taken to determine the levels of malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), and glutathione peroxidase (GPX) after the first, third and seventh post-burn days.ResultsIn the EGCG-treated burn group, SOD and GPX activity were significantly higher than in the burn control group. Additionally, MDA and TNF-α levels were significantly lower in the EGCG-treated burn group.ConclusionsBased on this study, it might be anticipated that EGCG treatment may be beneficial in burn injury cases.

42 keywords...

hide…