• Explore (NY) · May 2018

    Review Meta Analysis

    Efficacy and Safety of Xiaoyao Formula as an Adjuvant Treatment for Post-Stroke Depression: A Meta-Analysis.

    • Xin Jin, Menglin Jiang, Dandan Gong, Yuehua Chen, and Yu Fan.
    • Institute of Molecular Biology & Translational Medicine, the Affiliated People's Hospital, Jiangsu University, No. 8 Dianli Road, Zhenjiang, Jiangsu 212002, PR China.
    • Explore (NY). 2018 May 1; 14 (3): 224-229.

    ObjectiveTo systematically evaluate the efficacy and safety of Xiaoyao formula (XYF) as an adjuvant treatment of post-stroke depression (PSD) by conducting a meta-analysis.MethodsPubmed, Embase, Cochrane Library, CNKI, VIP, and Wanfang databases were searched up to May 2016. Randomized controlled trials investigating XYF plus antidepressants versus antidepressants alone for patients with PSD were considered.ResultsA total of 607 PSD patients were identified from 7 trials. Adjuvant treatment with XYF had additional benefits in terms of improved total response rates (risk ratio [RR] 1.21; 95% confidence interval [CI]: 1.12-1.30), reduced Hamilton's depressive scale (weighted mean difference [WMD] -5.21; 95% CI: -7.48 to -2.95), and decreased Scandinavian Stroke Scale (WMD -6.35; 95% CI: -8.27 to -4.43). No serious adverse events were observed in any of the included trials.ConclusionsAdjuvant treatment with XYF appears to have additional benefits in the treatment of PSD, without increasing serious adverse events.Copyright © 2018 Elsevier Inc. All rights reserved.

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