• Revista médica de Chile · May 2021

    Case Reports

    Taxane-induced scleroderma. Report of two cases.

    • Jade Cury-Martins, Laura Giesen, Sergio González, Montserrat Molgo, and Jose Antonio Sanches.
    • Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
    • Rev Med Chil. 2021 May 1; 149 (5): 807-809.

    AbstractTaxanes are a class of chemotherapeutic agents with common associated dermatologic adverse events, such as skin hyperpigmentation, hand-foot skin syndrome, paronychia and onycholysis. Taxane-induced scleroderma is rare. Few cases with skin findings resembling systemic sclerosis, have been reported after the administration of these agents. We report two cases with stage IV breast cancer, aged 66 and 71 years, who developed sclerodermic skin lesions in their extremities after starting treatment with placlitaxel and nabplaclitaxel respectively.

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