• Hospital formulary · Jul 1993

    Antineoplastic agents: comparing off-label uses among authoritative drug compendia.

    • D F Thompson and C C Keefe.
    • Southwestern Oklahoma State University, Weatherford.
    • Hosp Formul. 1993 Jul 1; 28 (7): 641-2, 647.

    AbstractUnlabeled indications for antineoplastic drugs listed in the American Hospital Formulary-Drug Information, United States Pharmacopeia Dispensing Information-Drug Information for the Health Care Professional (Volume 1), and the American Medical Association-Drug Evaluations were evaluated. Specifically, the total number of unlabeled and unique uses (ie, not listed in either of the other two compendia) of 35 antineoplastic drugs were compared. Using a nonparametric analysis of variance to evaluate the results, significant differences in both the average unlabeled indications per drug and unique unlabeled indications per drug were found among the resources checked. The implications of the study results on reimbursement by private insurance carriers of unlabeled antineoplastic drug use is discussed in this article.

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