• J Fam Pract · Apr 2005

    Review

    Clinical inquiries. Does anticoagulation prevent thrombosis for persons with fractures distal to the hip?

    • Julie Brogen, Gary Kelsberg, Sarah Safranek, Dana Nadalo, and Patricia Janki.
    • Valley Family Medicine Residency, Renton, WA, USA. Julie_Brogren@valleymed.org
    • J Fam Pract. 2005 Apr 1; 54 (4): 376-7.

    AbstractLow-molecular-weight heparin (LMWH) prophylaxis significantly reduces the total incidence of deep venous thrombosis (DVT) for patients with lower-limb fractures managed with surgical fixation and cast immobilization (strength of recommendation [SOR]: A, based on multiple randomized controlled studies [RCTs]). Evidence is insufficient to show whether LMWH specifically reduces the risk of clinically significant DVTs, and recommendations on its use are conflicting (SOR: C, based on expert opinion). Evidence is insufficient to recommend for or against warfarin prophylaxis for DVT in fractures distal to the hip (SOR: C, based on expert opinion).

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