• Majid Mahmoodi, Saeed Soleyman-Jahi, Kazem Zendehdel, Hossein Mozdarani, Cyrus Azimi, Farideh Farzanfar, Zahra Safari, Mohammad-Ali Mohagheghi, Malihea Khaleghian, Kouros Divsalar, Esfandiar Asgari, and Nima Rezaei.
• a Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences , Tehran , Iran.
• Drug Chem Toxicol. 2017 Apr 1; 40 (2): 235-240.

ObjectiveConcern exists regarding the possible hazards to the personnel handling anti-neoplastic drugs. The purpose of the present study was to assess the genotoxicity induced by anti-neoplastic agents in oncology department personnel.Materials And MethodsTo do this, the frequency of chromosomal aberrations (CAs) induced in peripheral blood lymphocytes was assessed at G0 phase of the cell cycle using metaphase analysis, cytokinesis block-micronucleus (MN) assay and sister chromatid exchange (SCE) assay. These cytogenetic end points were measured among 71 nurses in oncology department and 10 drugstore personnel handling and preparing anti-neoplastic drugs. The results were compared to those of 74 matched nurses for age and sex not exposed to any anti-neoplastic agents.ResultsThere was no significant difference between the age of study subjects and control group (p > 0.05). The results showed that the mean frequency of cytogenetic damages in terms of CAs [chromatid breaks (p = 0.01), chromosome breaks (p = 0.005), total CAs (p = 0.001)], MN formation (p = 0.001), and SCE (p = 0.004) in lymphocytes of personnel handling anti-neoplastic drugs were significantly higher than those in control unexposed group.ConclusionResults of the present study demonstrate the cytogenetic damage in peripheral blood lymphocytes of oncology department personnel. Suitable training and proper knowledge when handling anti-neoplastic drugs are emphasized to avoid potential health hazards caused by cytostatic agents.

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