Nephrogenic systemic fibrosis: a systemic fibrosing disease

Best Pract Res Clin Rheumatol · Aug 2012

Review

Nephrogenic systemic fibrosis: a systemic fibrosing disease resulting from gadolinium exposure.

Nephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs) during imaging procedures. NSF is characterised by skin thickening, tethering and hyperpigmentation; flexion contractures of joints; and extracutaneous fibrosis. This article reviews the history, clinical manifestations, epidemiology, histopathology and pathophysiology of this disabling disease.

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- Elana J Bernstein, Christian Schmidt-Lauber, and Jonathan Kay.
- Rheumatology Division, Hospital for Special Surgery, and Department of Medicine, New York-Presbyterian Hospital/Weill Cornell Medical College New York, NY 10021, USA.
- Best Pract Res Clin Rheumatol. 2012 Aug 1; 26 (4): 489-503.
AbstractNephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs) during imaging procedures. NSF is characterised by skin thickening, tethering and hyperpigmentation; flexion contractures of joints; and extracutaneous fibrosis. This article reviews the history, clinical manifestations, epidemiology, histopathology and pathophysiology of this disabling disease.Copyright © 2012 Elsevier Ltd. All rights reserved.

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Nephrogenic systemic fibrosis: a systemic fibrosing disease resulting from gadolinium exposure.

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