• Rebeca Rodriguez-Pena, Cristina Antunez, Enrique Martin, Natalia Blanca-Lopez, Cristobalina Mayorga, and TorresMaria JoseMJ.
• Carlos Haya Hospital, Research Laboratory for Allergic Diseases, Málaga, Spain.
• Expert Opin Drug Saf. 2006 Jan 1; 5 (1): 31-48.

AbstractAllergy to beta-lactam antibiotics is the most frequent cause of drug-induced immunological reactions, although the prevalence is not exactly known. IgE- and T-cell-dependent responses are the main mechanisms involved, although other immunological mechanisms can also participate, especially in haematological abnormalities, such as immune haemolytic anaemia or thrombocytopoenia. Aside from their frequency, the clinical entities reported nowadays have changed little since penicillin was first used. The variation in beta-lactams consumption through the year has modified the pattern and specificities of allergic reactions for IgE and T cell responses. Benzylpenicillin is no longer the beta-lactams most frequently prescribed and other chemical structures, with new or modified haptens, have progressively replaced it. This is relevant for the diagnostic evaluation and management of beta-lactam hypersensitivity.

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