• Int. Arch. Allergy Immunol. · Jan 1993

    Review

    Pathogenic significance and diagnostic value of lupus autoantibodies.

    • Y Tomer, D Buskila, and Y Shoenfeld.
    • Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel.
    • Int. Arch. Allergy Immunol. 1993 Jan 1; 100 (4): 293-306.

    AbstractSystemic lupus erythematosus (SLE) is characterized by a panoply of autoantibodies (more than 50). Some of them are more prevalent (anti-ds DNA > 80%) while others are less frequently detected, but highly specific for SLE (anti-Sm, 20%). In this review we will discuss the clinical significance of anti-RNP, anti-Ro, anti-La and anti-phospholipid antibodies. We will also summarize the clinical and experimental evidence for the pathogenic role attributed to each one of these antibodies.

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