• Turk J Anaesthesiol Reanim · Oct 2017

    Effective Loading Dose of Dexmedetomidine to Induce Adequate Sedation in Parturients Undergoing Caesarean Section Under Spinal Anaesthesia.

    • Jinguo Wang, Zhanyang Han, Honglan Zhou, Na Wang, and Haichun Ma.
    • Department of Urology, The First Hospital of Jilin University, Changchun, China.
    • Turk J Anaesthesiol Reanim. 2017 Oct 1; 45 (5): 260-263.

    ObjectiveTo calculate the effective dose (ED) of dexmedetomidine for caesarean section under spinal anaesthesia.MethodsConsecutive parturients scheduled for caesarean section under spinal anaesthesia were included. The loading dose of dexmedetomidine was evaluated using the up-and-down method, starting at 1.0 μg kg-1 and a step size of 0.1 μg kg-1. The loading dexmedetomidine was administrated by the venous route for 10 min, and afterwards a maintenance dose began at a rate of 0.3 μg kg-1 h-1 in all parturients. Adequate sedation was defined as a Ramsay sedation score ≥3. The ED50 and ED95 of loading dexmedetomidine were calculated using probit regression.ResultsThe ED50 and ED95 of loading dexmedetomidine for adequate sedation were 0.82 μg kg-1 (95% confidence intervals [CI] 0.73-0.89 μg kg-1) and 0.96 μg kg-1 (95% CI 0.90-1.39 μg kg-1), respectively.ConclusionThe ED50 and ED95 of loading dexmedetomidine to achieve adequate sedation were 0.82 μg kg-1 and 0.96 μg kg-1 for caesarean section under spinal anaesthesia.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…