• Hui Wu, Fangyi Dong, Ying Wang, Qin Xiao, Qiong Yang, Jing Zhao, Thomas J Quinn, Sheng-di Chen, and Jun Liu.
• Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Neurology, Minhang Hospital, Shanghai 201100, China.
• Parkinsonism Relat. Disord. 2014 Oct 1; 20 (10): 1094-6.

AbstractCatechol-O-methyltransferase (COMT) is one of the cardinal enzymes that metabolize dopamine and other catecholamine neurotransmitters in the central and peripheral nervous system. Recent studies have shown that the impact of COMT haplotypes on the development of wearing-off phenomenon is in dispute, while the relationship between COMT haplotypes and wearing-off phenomenon in ethnic Chinese population is lacking. The purpose of this study was to characterize the correlation between the Val158Met polymorphism in the COMT gene and the motor complication "wearing-off" in Chinese PD patients. We have sequenced the COMT gene in 259 PD patients and 257 healthy controls. Our results demonstrated that Met/Met homozygosity of the COMT Val158Met polymorphism was related to a decreased risk of developing wearing-off. This finding suggests that COMT Val158Met may affect susceptibility to wearing-off in PD. Copyright © 2014 Elsevier Ltd. All rights reserved.

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