• Antimicrob. Agents Chemother. · Apr 2019

    Cefepime Pharmacokinetics in Critically Ill Pediatric Patients Receiving Continuous Renal Replacement Therapy.

    • Gideon Stitt, Jennifer Morris, Lindsay Schmees, Joseph Angelo, and Ayse Akcan Arikan.
    • Department of Pharmacy Services, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA stittg@email.chop.edu.
    • Antimicrob. Agents Chemother. 2019 Apr 1; 63 (4).

    AbstractThis retrospective study included pediatric intensive care unit patients receiving continuous veno-venous hemodiafiltration (CVVHDF) being treated with cefepime. The free drug concentration above one time the MIC (fT>1×MIC) and four times a presumed MIC (fT>4×MIC) of 8 μg/ml were calculated. Four patients received doses ranging from 48 to 64 mg/kg of body weight every 6 to 12 h. Three patients achieved 100% fT>1×MIC, with the fourth patient achieving 98% fT>1×MIC. Therapeutic drug monitoring should be considered for critically ill patients receiving cefepime on CVVHDF.Copyright © 2019 American Society for Microbiology.

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