• Pharmacogenomics · Nov 2008

    Clinical Trial

    Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype.

    • Masakazu Hayashida, Makoto Nagashima, Yasuo Satoh, Ryoji Katoh, Megumi Tagami, Soichiro Ide, Shinya Kasai, Daisuke Nishizawa, Yasukazu Ogai, Junko Hasegawa, Hiroshi Komatsu, Ichiro Sora, Kenichi Fukuda, Hisashi Koga, Kazuo Hanaoka, and Kazutaka Ikeda.
    • Division of Psychobiology, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan.
    • Pharmacogenomics. 2008 Nov 1;9(11):1605-16.

    AimsThe association between SNPs of the human OPRM1 gene encoding the micro-opioid receptor and postoperative analgesic requirements in surgical patients remains controversial. Here, we evaluate whether any of the five tag SNPs (A118G, IVS2+G691C, IVS3+G5953A, IVS3+A8449G and TAA+A2109G) representing the four linkage disequilibrium blocks of the OPRM1 gene influences postoperative analgesic requirements.Materials & MethodsWe studied 138 adult Japanese patients who underwent major open abdominal surgery under combined general and epidural anesthesia and received continuous postoperative epidural analgesia with opioids.ResultsThe 118G homozygous (GG) patients required 24-h postoperative analgesics more than 118A homozygous (AA) and heterozygous (AG) patients. Tag SNP haplotypes also were associated with 24-h postoperative analgesic requirements.ConclusionsThese results suggest that OPRM1 gene tag SNP genotypes and haplotypes can primarily contribute to prediction of postoperative analgesic requirements in individual patients undergoing major open abdominal surgery.

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