• Maria Luisa de la Cruz Conty, Maria Begoña Encinas Pardilla, Marta Garcia Sanchez, Laura Gonzalez Rodriguez, Marta Luisa Muner-Hernando, Ana Royuela Vicente, Pilar Pintado Recarte, Alicia Martinez Varea, Clara Martinez Diago, Sara Cruz Melguizo, Oscar Martinez-Perez, and On Behalf Of The Spanish Obstetric Emergency Group.
• Fundacion de Investigacion Biomedica, Puerta de Hierro University Hospital of Majadahonda, 28222 Madrid, Spain.
• Vaccines (Basel). 2021 Jan 8; 9 (1).

AbstractThe COVID-19 pandemic has raised questions about the possible cross immunity resulting from common vaccination programs and SARS-CoV-2 infection. Therefore, the Spanish Obstetric Emergency group performed a multicenter prospective study on the vaccination status of Influenza and Tdap (diphtheria, tetanus and pertussis vaccine boost administered in adulthood) in consecutive cases of SARS-CoV-2 infection in a pregnancy cohort, in order to assess its possible association with the clinical presentation and severity of symptoms of SARS-CoV-2 infection, as well as to determine the factors that may affect vaccination adherence. A total of 1150 SARS-CoV-2 positive pregnant women from 78 Spanish hospitals were analyzed: 183 had not received either vaccine, 23 had been vaccinated for Influenza only, 529 for Tdap only and 415 received both vaccines. No association was observed between the vaccination status and the clinical presentation of SARS-CoV-2 infection and/or the severity of symptoms. However, a lower adherence to the administration of both vaccines was observed in the Latin-American subgroup. Based on the results above, we reinforce the importance of maternal vaccination programs in the actual pandemic. Health education campaigns should be specially targeted to groups less likely to participate in these programs, as well as for a future SARS-CoV-2 vaccination campaign.

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