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- Daisuke Tamanoi, Koichi Saruwatari, Kosuke Imamura, Ryo Sato, Takuya Jodai, Shohei Hamada, Yusuke Tomita, Sho Saeki, Shikiko Ueno, Yuji Yonemura, Hidenori Ichiyasu, and Takuro Sakagami.
- Department of Respiratory Medicine, Kumamoto University Hospital, Japan.
- Intern. Med. 2022 Jun 1; 61 (11): 1731-1734.
AbstractThe effect of radiotherapy during immunotherapy on immune-related adverse events (irAEs) is not fully understood. We herein report a 74-year-old woman diagnosed with lung adenocarcinoma with programmed death ligand 1 expression ≥50% and treated with pembrolizumab. She developed fatal immune thrombocytopenia associated with pembrolizumab immediately following radiotherapy. A flow cytometry analysis of peripheral blood detected an increased expression of programmed death-1 (PD-1) and Ki-67 in CD4+ and CD8+ T cells after radiotherapy, compared with pre-irradiation measurements. This case suggests that radiotherapy may evoke irAEs during treatment with anti-PD-1 antibodies, which physicians should consider when using radiotherapy in patients treated with these drugs.
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