• Internal medicine · Jun 2022

    Case Reports

    The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient: A Case Report.

    • Hiroki Kobayashi, Yusuke Yoshida, Tomoki Komoshita, Harumichi Suma, Yohei Hosokawa, Yoshikazu Hirose, Tomohiro Sugimoto, Sho Mokuda, Shintaro Hirata, and Eiji Sugiyama.
    • Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
    • Intern. Med. 2022 Jun 1; 61 (11): 1785-1788.

    AbstractWe herein report the case of a 78-year-old woman who was diagnosed as having disseminated herpes zoster (DHZ) complicated with probable varicella-zoster pneumonia during maintenance therapy for microscopic polyangiitis. Because the patient had severe renal dysfunction, amenamevir administration was started to avoid any neurotoxicity of acyclovir, which is suggested to be optimal for treatment. It ameliorated her symptoms without any adverse events. This is the first report suggesting the efficacy of amenamevir in the treatment of severe herpes zoster infection with coexisting DHZ and probable varicella-zoster pneumonia. Amenamevir could thus be a treatment option for severe varicella zoster virus infections.

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