• Internal medicine · Jun 2022

    Case Reports

    An Autopsy Case of An Acute Exacerbation of Idiopathic Pulmonary Fibrosis Triggered by the Inhalation of a Waterproofing Spray.

    • Takako Kawaguchi, Takashi Tachiwada, Kei Yamasaki, Kei Nakamura, Eisuke Katafuchi, Masahiro Tahara, Yu Isoshima, Hidenori Ohira, Hiroki Kawabata, Kanako Hara, and Kazuhiro Yatera.
    • Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan.
    • Intern. Med. 2022 Jun 15; 61 (12): 1881-1886.

    AbstractAn 82-year-old Japanese man with idiopathic pulmonary fibrosis (IPF) experienced dyspnea after using a waterproofing spray in a closed room. He presented with hypoxemia and his chest computed tomography showed additive bilateral diffuse ground-glass attenuation on fibrosis, which was diagnostic of an acute exacerbation of IPF (AE-IPF). Combined treatment with high-dose corticosteroids and immunosuppressants were ineffective, and he later died of respiratory failure. Autopsy findings showed diffuse alveolar damage with honeycombing. His medical history and autopsy histopathology suggested AE-IPF caused by the inhalation of a waterproofing spray.

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