• Mult. Scler. · May 2018

    Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis.

    • Burcu Zeydan, Val J Lowe, Christopher G Schwarz, Scott A Przybelski, Nirubol Tosakulwong, Samantha M Zuk, Matthew L Senjem, Jeffrey L Gunter, Rosebud O Roberts, Michelle M Mielke, Eduardo E Benarroch, Moses Rodriguez, Mary M Machulda, Timothy G Lesnick, David S Knopman, Ronald C Petersen, Clifford R Jack, Kejal Kantarci, and Orhun H Kantarci.
    • Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA/Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA.
    • Mult. Scler. 2018 May 1; 24 (6): 739-749.

    BackgroundThere is growing interest in white matter (WM) imaging with positron emission tomography (PET).ObjectivesWe studied the association of cognitive function in late multiple sclerosis (MS) with cortical and WM Pittsburgh compound-B PET (PiB-PET) binding.MethodsIn the population-based Mayo Clinic Study of Aging, 24 of 4869 participants had MS (12 underwent PiB-PET). Controls were age and sex matched (5:1). We used automated or semi-automated processing for quantitative image analyses and conditional logistic regression for group differences.ResultsMS patients had lower memory ( p = 0.03) and language ( p = 0.02) performance; smaller thalamic volumes ( p = 0.003); and thinner temporal ( p = 0.001) and frontal ( p = 0.045) cortices on magnetic resonance imaging (MRI) than controls. There was no difference in global cortical PiB standardized uptake value ratios between MS and controls ( p = 0.35). PiB uptake was lower in areas of WM hyperintensities compared to normal-appearing white matter (NAWM) in MS ( p = 0.0002). Reduced PiB uptake in both the areas of WM hyperintensities ( r = 0.65; p = 0.02) and NAWM ( r = 0.69; p = 0.01) was associated with decreased visuospatial performance in MS.ConclusionPiB uptake in the cortex in late MS is not different from normal age-matched controls. PiB uptake in the WM in late MS may be a marker of the large network structures' integrity such as those involved in visuospatial performance.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…