-
Case Reports
Rapidly progressive glomerulonephritis associated with PR3-ANCA positive subacute bacterial endocarditis.
- Hirotaka Fukasawa, Maho Hayashi, Naoko Kinoshita, Sayaka Ishigaki, Shinsuke Isobe, Yukitoshi Sakao, Akihiko Kato, Yoshihide Fujigaki, and Ryuichi Furuya.
- Renal Division, Department of Internal Medicine, Iwata City Hospital, Japan. hfukasawaucsd@gmail.com
- Intern. Med. 2012 Jan 1; 51 (18): 2587-90.
AbstractPatients with bacterial endocarditis often have renal complications. This report presents the case of an elderly man with rapidly progressive glomerulonephritis (RPGN) associated with subacute bacterial endocarditis (SBE) due to Enterococcus faecalis infection. The patient was positive for anti-proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA) and rheumatoid factor (RF) with hypocomplementemia. Treatment for SBE with antibiotics and the surgical replacement of the affected valves resulted in an improvement of RPGN, the disappearance of PR3-ANCA and RF, and the normalization of hypocomplementemia. This rare case suggests the importance of recognizing the cause of positive PR3-ANCA, because SBE could be an occult cause of RPGN mimicking ANCA-associated vasculitis.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..