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American heart journal · Jan 2019
Randomized Controlled Trial Multicenter Study Pragmatic Clinical TrialAn international cluster-randomized quality improvement trial to increase the adherence to evidence-based therapies for acute ischemic stroke and transient ischemic attack patients: Rationale and design of the BRIDGE STROKE Trial.
- Maria Julia Machline-Carrion, Eliana Vieira Santucci, Lucas Petri Damiani, Cecilia Bahit, Germán Málaga, Octávio Marques Pontes-Neto, MartinsSheila Cristina OuriquesSCOHospital das Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Viviane Flumignan Zétola, Karina Normilio-Silva, de FreitasGabriel RodriguesGRInstituto D'Or de Ensino e Pesquisa, Rio de Janeiro, RJ, Brazil., Alessandra Gorgulho, Antônio De Salles, da SilvaBeatriz Gonzales PachecoBGPResearch Institute HCor-Hospital do Coração, São Paulo, SP, Brazil., Juliana Yamashita Santos, de Andrade JesuínoIsabellaIResearch Institute HCor-Hospital do Coração, São Paulo, SP, Brazil., Priscila Regina Torres Bueno, Alexandre Biasi Cavalcanti, Hélio Penna Guimarães, Ying Xian, Janet Prvu Bettger, Renato D Lopes, Eric D Peterson, and Otávio Berwanger.
- Research Institute HCor-Hospital do Coração, São Paulo, SP, Brazil. Electronic address: mjuliacarrion@gmail.com.
- Am. Heart J. 2019 Jan 1; 207: 49-57.
BackgroundTranslating evidence into clinical practice in the management of acute ischemic stroke (AIS) and transient ischemic attack (TIA) is challenging especially in low- and middle-income countries.ObjectivesThe aim of this study is to assess the effect of a multifaceted quality improvement intervention on adherence to evidence-based therapies for AIS and TIA patients care.DesignWe designed a pragmatic, 2-arm cluster-randomized trial involving 36 clusters and 1624 patients from Brazil, Argentina, and Peru. Hospitals are randomized to receive a multifaceted quality improvement intervention (intervention group) or to routine care (control group). The BRIDGE Stroke multifaceted quality improvement intervention includes case management, reminders, health care providers' educational materials (including treatment algorithms), interactive workshops, and audit and feedback reports. Primary outcome is a composite adherence score to AIS and TIA performance measures. Secondary outcomes include an "all or none" composite end point to performance measures, the individual components of the composite end points, and clinical outcomes at 90 days following admission (stroke recurrence, death, and disability measured by the modified Rankin scale).SummaryThe BRIDGE Stroke Trial is an international pragmatic evaluation of a multifaceted quality improvement intervention. If effective, this intervention could be potentially extended widely to improve the quality of care and outcomes of patients with AIS or TIA.Copyright © 2018 Elsevier Inc. All rights reserved.
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