• Curr Opin Ophthalmol · May 2015

    Review

    Optogenetics.

    • Jens Duebel, Katia Marazova, and José-Alain Sahel.
    • aInstitut de la Vision, Sorbonne Universités, UPMC Univ Paris, UMR_S 968 bINSERM, U_968 cCNRS, UMR_7210 dCentre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU ViewMaintain, INSERM-DHOS CIC 1423 eFondation Ophtalmologique Rothschild, Paris, France fInstitute of Ophthalmology-University College London, London, UK.
    • Curr Opin Ophthalmol. 2015 May 1; 26 (3): 226-32.

    Purpose Of ReviewIn this review, we will discuss the recent developments in optogenetics and their potential applications in ophthalmology to restore vision in retinal degenerative diseases.Recent FindingsIn recent years, we have seen major advances in the field of optogenetics, providing us with novel opsins for potential applications in the retina. Microbial opsins with improved light sensitivity and red-shifted action spectra allow optogenetic stimulation at light levels well below the safety threshold in the human eye. In parallel, remarkable success in the development of highly efficient viral vectors for ocular gene therapy led to new strategies of using these novel optogenetic tools for vision restoration.SummaryThese recent findings show that novel optogenetic tools and viral vectors for ocular gene delivery are now available providing many opportunities to develop potential optogenetic strategies for vision restoration.

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