• Mingchao Li, Xiaoqing Shi, Songjiang Yin, Li Zhang, Peng Wu, Taiyang Liao, Lishi Jie, and Peimin Wang.
• Department of Orthopaedic Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine; 155 Hanzhong Road, Nanjing, Jiangsu, China.
• Medicine (Baltimore). 2021 Nov 19; 100 (46): e27820e27820.

BackgroundTo evaluate the effect of synovectomy performed during primary total knee arthroplasty for knee osteoarthritis on patients' postoperative pain and knee function.MethodsWe will search the following electronic databases from inception to June 2021, including PubMed, EMBASE, Web of Science, the Cochrane Library, the China National Knowledge Infrastructure, the Chinese Scientific Journals Database, the Wanfang database, and the Chinese Biomedicine Database. Eligible references will be all randomized controlled trials of initial total knee arthroplasty for primary knee osteoarthritis with or without synovectomy. Two reviewers will independently extract the data. Reviewer Manager 5.3 software will be used for statistical analysis.ResultIt will provide results on the short- and long-term efficacy and safety of synovectomy in total knee arthroplasty by various comprehensive assessments.ConclusionThis study will provide solid evidence on whether and when synovectomy treatment should be performed during total knee arthroplasty.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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