• Medicine · Nov 2021

    Meta Analysis

    Association between helicobacter pylori infection and subclinical atherosclerosis: A systematic review and meta-analysis.

    • Xianghong Wang, Qian He, Donghua Jin, Baohua Ma, Kecheng Yao, and Xiulan Zou.
    • Department of Endocrinology, The Third Clinical Medical College of China Three Gorges University/Gezhouba Central Hospital of Sinopharm, Yichang, Hubei Province, China.
    • Medicine (Baltimore). 2021 Nov 19; 100 (46): e27840e27840.

    BackgroundThe relationship between Helicobacter pylori (H. pylori) infection and subclinical atherosclerosis has been confirmed, but these conclusions are still controversial. Therefore, we have performed a systematic review and meta-analysis to assess the association between H. pylori infection and subclinical atherosclerosis.MethodsDatabases including PubMed, Embase, Web of Science were searched for the articles on the association of carotid intima-media thickness or pulse wave velocity with H. pylori infection published up to January 1, 2020. Stata 12.0 was used to calculate standardized mean difference (SMD) and 95% confidence interval (95% CI); the I2 test was used to evaluate heterogeneity between studies and sensitivity analysis and subgroup analysis were used to explore the source of heterogeneity. Funnel plot, Begg test, and Egger test were used to estimate publication bias.ResultsData were extracted from 18 studies involving 6776 subjects with H. pylori positive and 7794 with H. pylori negative. H. pylori positive subjects is significantly associated with increased subclinical atherosclerosis as determined by carotid intima-media thickness (SMD: 0.376 mm; 95% CI: 0.178, 0.574; P < .001, I2 = 90.6%), pulse wave velocity (SMD: 0.320 m/s; 95% CI: 0.242, 0.398; P < .001, I2 = 52.6%), compared with H. pylori negative. Similar results were observed when subgroups analysis were stratified according to age, male ratio, geographical location, H. pylori diagnosis, and study design. Sensitivity analyses showed that our results were robust. The Begg test or Egger test showed no significant publication bias (all P > .05).ConclusionsThis meta-analysis confirmed a significant association between H. pylori and subclinical atherosclerosis, which will help H. pylori patients to establish effective strategies for the prevention and control of cardiovascular events.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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