• Expert Opin Pharmacother · Jan 2014

    Randomized Controlled Trial Multicenter Study

    Combined long-acting bronchodilator single therapy for COPD.

    • Ruxandra Mioara Râjnoveanu, Sabina Antoniu, and Ruxandra Ulmeanu.
    • University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Faculty of Medicine-Pulmonary Disease , 6 B.P. Hasdeu Street, Cluj-Napoca, 400371 , Romania.
    • Expert Opin Pharmacother. 2014 Jan 1; 15 (1): 139-42.

    IntroductionIn COPD, the long-acting bronchodilators are not always able to provide an appropriate bronchodilator effect in terms of amplitude and duration and this can result in increased severity of respiratory symptoms and in worsening of health status. Combined long-acting bronchodilators can address this limitation.Areas CoveredAnalysis of a recent study evaluating the efficacy and safety of 26 weeks of therapy with glycopyrronium+indacaterol single inhaler (QVA149) versus each component, versus tiotropium and versus placebo.Expert OpinionSuch a combination can provide a superior and sustained bronchodilator effect and can minimize the respiratory symptoms resulting from a suboptimally inhibited bronchoconstriction.

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