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Pol. Merkur. Lekarski · Jan 2011
Editorial[Novel controllers of airway obstruction in COPD patients].
- Tadeusz Płusa.
- Wojskowy Instytut Medyczny w Warszawie, Klinika Chorób Wewnetrznych, Pneumonologii i Alergologii CSK MON.
- Pol. Merkur. Lekarski. 2011 Jan 1; 30 (175): 5-9.
AbstractFor improving effectiveness of chronic obstructive pulmonary disease (COPD) therapy is necessary to influence on pharmacologic receptors in the complementary way and to reduce the dose frequency. The once-daily dose administration is an important step which may allow to enhance of patients compliance. Novel long-acting bronchodilators--beta2-agonists or ultra long-acting beta2-agonists (LABAs) such as indacaterol and carmoterol--are under clinical application for the treatment of COPD patients. Moreover, some new long-acting antimuscarinic agents (LAMA) (aclidinium, glycopyrrolate) and dual-action ultra LABA+LAMA combination products are under development. The main target of therapeutic research is to produce a dimmer molecule known as M3 antagonist-beta2 agonist (MABA) bronchodilators which will open the door for a new range of combination products.
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