• J Thorac Oncol · Apr 2011

    The feasibility study of Carboplatin plus Etoposide for advanced small cell lung cancer with idiopathic interstitial pneumonias.

    • Yuji Minegishi, Hidehiko Kuribayashi, Kazuhiro Kitamura, Hideki Mizutani, Seiji Kosaihira, Tetsuya Okano, Masahiro Seike, Arata Azuma, Akinobu Yoshimura, Shoji Kudoh, and Akihiko Gemma.
    • Division of Pulmonary medicine, Infectious disease, and Oncology, Department of Internal Medicine, Nippon Mediccl School, Tokyo, Japan. yminegis@nms.ac.jp
    • J Thorac Oncol. 2011 Apr 1; 6 (4): 801-7.

    BackgroundIdiopathic interstitial pneumonias (IIPs) are among the most common complications in patients with lung cancer. In such patients with cancer, the most serious expression of toxicity in Japan is acute exacerbation of IIPs caused by anticancer treatment. Nevertheless, there has been no consensus and no evidence presented, regarding optimal treatment for advanced lung cancer with IIP.Patients And MethodsChemotherapy-naive patients with advanced small cell lung cancer (SCLC) with IIP who were ineligible for curative radiotherapy were enrolled. Patients received carboplatin every 21 days at a dose of area under the curve 6.0 on day 1 and etoposide at a dose of 100 mg/m on days 1 to 3.ResultsBetween July 2002 and October 2008, 17 patients with SCLC with IIP, including 14 men, eight of whom were diagnosed with idiopathic pulmonary fibrosis, were enrolled and treated for a mean of 3.5 cycles of carboplatin plus etoposide. One patient (5.9%; 95% confidence interval, 0-18.4%) with clinically confirmed idiopathic pulmonary fibrosis had acute exacerbation of IIPs associated with the treatment. The overall response rate was 88.2%. The median progression-free survival, median survival time, and 1-year survival rate were 5.5 months, 8.7 months, and 29.4%, respectively.ConclusionThis is the first report indicating that patients with advanced SCLC with IIPs may benefit from chemotherapy. Patients with advanced SCLC with IIP treated with etoposide and carboplatin combination chemotherapy gain benefits, with safety equivalent to that seen in patients without IIP. The results from this study would support, on ethical grounds, the conduct of a large-scale study to evaluate this regimen.

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